Becker's Spine Review

31 DEVICES & IMPLANTS of units sold increasing 16 percent to 2,821. Implanet presented studies showing the system offers a safe alternative to traditional techniques and concluding the system appears to lower hospital costs for spinal fusion surgeries for adolescent idiopathic scoliosis. In February, Implanet finalized an agreement to work with L&K Biomed's U.S. subsidiary Aegis Spine to expand Jazz distribution. K2M (Leesburg, Va.). K2M is known for developing minimally invasive solutions for complex spinal disorder correction. A trailblazer in the 3-D printing of spinal devices, K2M launched a system for restoring cervical sagittal balance through posterior fixation in March and helps surgeons achieve 3-D spinal balance across the axial, coronal and sagittal planes through its Balance ACS platform. e company's comprehensive offerings boosted it to between $257.5 million and $258.1 million in preliminary reported revenue for fiscal year 2017, a 9 percent year-over-year increase. In March, the company committed to researching the outcomes of operative and nonoperative treatment for adult symptomatic lumbar scoliosis patients in collaboration with the Scoliosis Research Society and other organizations. Life Spine (Huntley, Ill.). Life Spine has created more than 60 solutions for addressing spinal pathology from the occiput to the sacrum and launched 21 products in 2017 alone, building out its portfolio focused on fusion and minimally invasive surgeries. Driven by a 493 percent boost over 2016 in revenues for its ProLi Expandable Spacer System with reduced gra subsidence, the company posted 36 percent year-over-year growth overall in 2017. While pushing additional micro-invasive technologies, Life Spine unveiled clinical advancements to its procedural solutions; earned FDA clearance for its Plateau-Lo Insert and Rotate Spacer System; and announced the first clinical use of SENTRY 2 Lateral Plating System in the first quarter of 2018. Mazor Robotics (Caesarea, Isreal). In 2017, Mazor Robotics hit $64.9 million in revenue and saw purchase orders soar: it clinched 27 in the fourth quarter alone. With Medtronic's $40 million investment in 2017 to assume global spine market commercial responsibility for the Mazor X Surgical Assurance Platform and accessories, Mazor received 64 robotic system orders for the Mazor X system for the year, out of 73 total. e company plans to emphasize synergy with Medtronic and procedure growth this year, riding the momentum of accelerating adoption of robotics for spine surgeries. Medacta (Castel San Pietro, Switzerland). As the first European-based international hip and knee manufacturer, Medacta had an average growth of 25 percent compared to the global market's 3 percent growth. rough the Medacta for Life Foundation, the company opened the My Baby nursery school and the My Child preschool in 2011 and 2015, respectively, which offer bilingual curricular and extracurricular activities for local children and continued expanding in 2018. When One World Surgery sent a team of 22 medical professionals to Honduras between Hurricanes Harvey and Irma in September 2017, the Medacta for Life Foundation provided 20 joints and other surgical instrumentation to professionals to perform 15 total knee replacements and five total hip replacements in just four days. Medicrea (Rillieux-la-Pape, France). Medicrea has designed, manufactured and distributed more than 30 FDA-approved spinal implant technologies for use in more than 150,000 procedures. e company's U.S. sales for the first quarter of 2018 amounted to $4.4 million, a 7 percent increase over the first quarter of 2017. A 60 percent increase in the number of personalized surgeries drove a 40 percent boost in sales for Medicrea's UniD ASI patient- specific technology platform, which represents 55 percent of total sales. Meditech Spine (Atlanta). As part of its vision to make a positive difference in the marketplace, Meditech Spine partners with nonprofit organization Cure International and sponsors children in developing countries to undergo spinal surgery. A portion of proceeds from each sale of Meditech's CURE LP plate help Cure International treat young patients in underserved areas, the company announced when its CURE Lumbar Plating System received FDA clearance in June 2017. Meditech also won FDA clearance that month for its Talos Lumbar (HA) Peek IBF for lumbar fusion procedures. Medtronic (Minneapolis). Medtronic is a medical device manufacturer operating in more than 160 countries with more than 370 locations worldwide; the company employs more than 84,000 people. In early 2018, Medtronic released a restructuring plan expected to save $3 billion by 2022 while keeping the total employee count steady. A few months prior, Medtronic completed its $40 million investment in Mazor Robotics for exclusive distribution rights to the Mazor X Surgical Assurance Platform and accessories for robotic assisted spinal procedures. Medtronic reported $7.3 billion in third quarter 2018 revenue, a 1 percent increase over the same period last year. Mesoblast (Melbourne, Australia). Mesoblast is a regenerative medicine company with a proprietary technology platform based on mesenchymal lineage adult stem cells. e company aims to have the first industrially manufactured allogeneic stem cell product approved in the U.S. with its product candidate remestemcel-L (MSC-100-IV) for the treatment of acute Gra Versus Host Disease in pediatric patients. As of Dec. 31, 2017, Mesoblast had cash reserves of $47.4 million. Mesoblast recently completed enrollment for its Phase 3 mesenchymal cell therapy trial to treat chronic low back pain due to degenerative disc disease. Mizuho OSI (Union City, Calif.). Mizuho OSI is known for its surgical tables designed for spinal surgery, hip replacement, knee replacement and orthopedic trauma procedures. However, the company is expanding to become a full-OR solution; Mizuho OSI is the nation's second-largest supplier of over-bed traction equipment, patient care and pressure management products. In October 2017, Mizuho OSI unveiled the Levó Head Positioning System at the North American Spine Society Oct. 25 to Oct. 27 in Orlando, Fla., annual meeting; the system uses electro-mechanical technology to give physicians control and precision in head positioning for all spine procedures. NuVasive (San Diego). NuVasive develops minimally disruptive and procedurally integrated spinal surgery solutions. e company is best known for its eXtreme Lateral Interbody Fusion (XLIF) procedure and also offers the Maximum Access Surgery platform for minimally invasive spine surgery. NuVasive employs 2,300 people at more than 25 locations across the globe and reported $1.03 billion in full-year 2017 revenue. NuVasive recently unveiled its Anterior Lumbar Interbody Fusion Access, NuVasive's first Maximum Access Surgery ALIF retractor platform for both lateral and supine spine surgery. Orthofix (Lewisville, Texas). Orthofix has approximately 900 employees worldwide developing orthopedic and spine products and regenerative tissue forms. In 2017, Orthofix's net sales hit $116.9 million; its spine fixation segment reached net sales of nearly $82 million. Orthofix recently acquired artificial disc company Spinal Kinetics for up to $105 million. Paradigm Spine (New York City). Paradigm Spine is a non-fusion spinal implant technology company, offering the coflex Interlaminar Stabilization device, the coflex-F and the DSS stabilization system. In January, Paradigm Spine published two-year trial results of its European Study of coflex And Decompression Alone in

• Cover