Becker's Spine Review

30 DEVICES & IMPLANTS 36 spine & orthopedic device companies to know By Shayna Korol and Angie Stewart T he medical technology landscape is changing, with orthopedic and spine device companies growing, developing new technologies and partnering for unique innovations. Here are 36 orthopedic and spine device companies to know. e companies are listed in alphabetical order. Astura Medical (Carlsbad, Calif.). Astura Medical received FDA clearance for its Bridalveil OCT system in October 2017, marking the launch of its 11th spinal implant and instrumentation system since the company was created in December 2014. Aer two years in business, Astura Medical completed its first portfolio of products with the Half Dome Posterior Lumbar Interbody Spacer, Olympic Posterior Spinal Fixation System, Alta Anterior Cervical Interbody Spacer and Zion Anterior Cervical Fixation System. Astura expects that suite of products to continue building on its 312 percent growth in annual revenue in 2017 and plans to launch its MIS Platform later this year. Camber Spine (Wayne, Pa.). Camber Spine accomplished 46 percent annual growth in 2017, a year that was kicked off with FDA clearance of its Siconus SI Joint Fixation System and defined by a 97 percent increase in active surgeon users. e year was bookended with FDA clearance of the Spira-C Open Matrix Cervical Interbody, which was successfully used in multilevel ACDF procedures for the first time in February. Building on those achievements, Camber Spine expects to launch three products — the second generation of ENZ MIS ALIF, SPIRA-L Open Architecture Lateral Cage and SPIRA V Open Matrix Corpectomy — and gain FDA approval for another six procudts. Captiva Spine (Jupiter, Fla.). Founded in 2007, Captiva Spine has built a targeted portfolio of lumbar and cervical spine fusion products featuring screw systems, cages, morsels and putty and a plate system. In March, the company announced the first successful cases using its TransFasten Posterior SI Fusion System, which launched in October 2017, and plans to train surgeons on the posterior SI approach nationwide. e privately held company signaled further growth by hiring Daniel Abromowitz as vice president of sales and business development and launching its HyperLOX posterior cervical system, a solution for posterior stabilization and fusion of the cervical and thoracic spine. Carl Zeiss AG (Jena, Germany). In 2017, Carl Zeiss achieved its most successful fiscal year in company history that spans 170 years: revenue rose by 10 percent to a record level of approximately $6.6 billion, and all four of the company's business segments reported positive returns, including about $1.8 billion in revenue for the medical technology segment. In the first quarter of 2018, Carl Zeiss Meditec continued the positive trend with 4.2 percent revenue growth in its ophthalmic devices business unit and 8.2 percent revenue growth in its microsurgery segment. Carl Zeiss offers several spine visualization systems — the Kinevo 900, OPMI Pentero 800, OPMI Vario 700 and Surgical Loupes — that utilize a surgical microscope to improve patient outcomes in minimally invasive procedures. Centinel Spine (West Chester, Pa.). Centinel Spine was born in 2008 out of the merger- acquisition of nucleus replacement devices leader Raymedica and integrated interbody trailblazer Surgicra. e company launched its cervical device the same year. In December 2017, Centinel re-acquired the prodisc total disc replacement portfolio from DePuy Synthes Products, a line of products with the longest history of use globally, with intentions of focusing on the U.S. and Australian markets. Shortly aer the deal closed, Centinel reported it pulled in $132 million from investors. ChoiceSpine (Knoxville, Tenn.). Offering a regenerative and osteobiologics portfolio complete with synthetics, demineralized bone matrix putties, structural allogra and amnion allogras, ChoiceSpine lays claim to 18 patents. e 12-year-old, privately held company received FDA clearance for its TOMCAT standalone cervical device at the end of 2015 and in 2017 reported the 1,000th successful anterior cervical discectomy and fusion procedure using TOMCAT. Following that milestone, ChoiceSpine won FDA clearance for its Blackhawk integrated anterior cervical fusion device and Hawkeye Ti 3D-printed, titanium vertebral body replacement device, which achieved its first clinical use in December 2017. CTL Medical Corp. (Dallas). Founded in 2015, CTL Medical scooped up RF Precision and AccelSpine in 2016 and has established itself as a major player in the pedicle screw systems market with more than 10 full-time engineers and in-house manufacturing capabilities. In July 2017, CTL entered an agreement to co-market the bone cement, kyphoplasty and vertebroplasty technologies of G-21, a biomaterials company, building on its 2016 partnership with Firehouse Medical to sell its spinal implants and devices to the U.S. government. e company secured FDA clearance for two systems in the first quarter of 2018: the Seurat Universal Pedicle Screw System and the Matisse Ti-Peek ACIF Cage System with TiCro. DePuy Synthes Spine (Raynham, Mass). Johnson & Johnson integrated the DePuy and Synthes businesses in 2012 to create an orthopedic and neurological powerhouse, DePuy Synthes Co. DePuy Synthes Spine made one of the biggest orthopedic device company acquisitions of 2017, scooping up a nerve localization technology company known as Sentio for an undisclosed amount. DePuy secured a $260 million contract from the Department of Defense last year for its orthopedic products, which comprise a portfolio the company claims is one of the world's most comprehensive. Elliquence (Baldwin, N.Y.). Elliquence has earned its status as a pioneer in endoscopic spine products and continues expanding its product line. To accommodate high demand for its endoscopic decompression procedures, the company is adding members to its team as well as growing and constructing training facilities. Elliquence's patented radiofrequency technology — developed nearly five decades ago — helps surgeons preserve healthy tissues by utilizing high-frequency, low-temperature radio waves in traditional scalpel, scissor, electrosurgical and laser assisted procedures. Globus Medical (Audubon, Pa.). Globus Medical is a force in the orthopedic and spine surgery device markets with a product line of more than 100 spine products — it launched nine in 2017. Aer launching its Excelsius GPS robotic surgical system in August 2017, the 15-year-old musculoskeletal solutions company posted a 16.1 percent increase in fourth quarter sales worldwide and hit $636 million in global sales for the year. Globus Medical has now splashed into the orthopedic trauma market with FDA clearance on 11 new products in the segment. Implanet (Martillac, France). Implanet's flagship product for treatment of spine pathologies resulting in vertebral fusion, the Jazz implant generated $1.47 million in revenue in the fourth quarter of 2017, with the number

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