Becker's Spine Review

32 DEVICES & IMPLANTS the Journal of Neurosurgery Spine. Paradigm Spine also commissioned a 2015 Milliman study into the economic value of colfex, which found reduced costs compared to primary lumbar fusion. SeaSpine (Carlsbad, Calif.). SeaSpine develops orthobiologics and spinal fusion technologies. e company markets it products in the U.S. and in more than 30 countries worldwide. SeaSpine reported revenue of $131.8 million for 2017, an increase of 2.3 percent over 2016, and U.S. revenue of $118.4 million for 2017, a 4.4 percent increase over the previous year. e company recently expanded its Ventura NanoMetalene posterior interbody device to accommodate a wider range of posterior procedures and patient anatomies. SI-Bone (Santa Clara, Calif.). Founded in 2008 as Inbone, a spin off from Wright Medical, SI-Bone developed iFuse, a patent for the minimally invasive sacroiliac join fusion implant system. Since then, more than 30,000 minimally invasive SI joint fusions have been performed with the device by more than 1,500 surgeons worldwide. e device has been gaining coverage determinations since 2009, most recently announcing Blue Cross Bleu Shield Association increased its clinical evidence rating for minimally invasive SI joint fusions in January. Spinal Elements (Carlsbad, Calif.). Spinal Elements develops spinal implants and instruments and offers cervical, lumbar, thoracolumbar and biologics products. Amendia acquired Spinal Elements, forming one company under the "Spinal Elements" name in April 2017 to yield a portfolio of titanium-coated PEEK interbody technology. Spinal Elements develops Ti-Bond porous titanium coating, complementing Amendia's Overwatch pedicle screw system, Syzygy reduction screw system and Ceres cervical product lines. Spineart (Irvine, Calif.). Spineart markets a portfolio combining traceable bar-coded sterile- packed implants with compact instrument sets. e privately held company offers minimally invasive surgery, motion preservation, fusion, biologics and fracture treatment solutions. Spineart offers an alternative to pedicle screw fixation with its 360° P-Screwless platform for minimally invasive circumferential fusion. e company is represented in over 55 countries and has 15 ongoing projects in its research and development pipeline. SpineCra (Westmont, Ill.). SpineCra develops products for spine deformities and complex spine problems, minimally invasive spine surgery, cervical and thoracolumbar degenerative conditions, non-fusion applications, orthobiologics and bone substitutes. In February 2017, SpineCra entered into an agreement with Mighty Oak Medical to use the FireFly Mechanical Surgical Guidance System with SpineCra Astra & Apex Spine Systems for complex spine and deformity correction. SpineCra also offers systems for minimally invasive spine surgery. Stryker Spine (Allendale, N.J.). Stryker saw $12.4 billion in net sales for 2017, with spine sales reaching $2.2 billion. In March, Stryker Spine announced its Tritanium C Anterior Cervical Cage was implanted by 311 surgeons since its October 2017 launch. Stryker Spine's spinal biologics offerings include traditional and proprietary spinal allogras, demineralized bone matrix products and a viable bone matrix. In 2017, Stryker reported employing 33,000 people across all of its service lines. Titan Spine (Mequon, Wis.). Titan Spine was established in 2006 and focuses on designing and manufacturing titanium interbody cage devices that promote spinal fusion. Titan Spine's proprietary nanoLOCK surface technology is engineered to enhance bone growth response at the macro and nanosurface levels. In 2016, CMS created a new technology ICD-10 code for interbody fusion procedures using nano-textured interbody fusion devices; nanoLOCK is currently the only device with access to use the code. e surface technology company employs about 110 people and has been growing at over 40 percent per year for over 10 years. TranS1 (Denver). TranS1 develops solutions designed to minimize the damage caused by surgical approaches to the spine. e company's foundational solution, the Axial Lumbar Interbody System — AxiaLIF+ — is manufactured to address spinal pathology at the L5-S1 vertebral bodies. TranS1 recently received three patents, two of which focus on presacral interbody fusion and one related to a new technique for sacroiliac fusion. Over the past three years, TranS1 has received 100-plus issued patents and has 50-plus new patent applications. Vertiflex (Carlsbad, Calif.). Vertiflex offers treatments for lumbar stenosis. Its minimally invasive motion-preserving Superion Interspinous Spacer System is indicated for moderate lumbar spinal stenosis. In 2017, Vertiflex completed a $40 million financing round for the U.S. commercial expansion of the Superion Indirect Decompression System, an implant for treating lumbar spinal stenosis. e device is designed to reduce pressure on impacted nerves. Vertiflex's Totalis Direct Decompression System is designed for minimally invasive direct decompressions of the lumbar spine. Wenzel Spine (Austin, Texas). Wenzel Spine provides minimally invasive solutions for the treatment of spinal disorders. In 2017, Wenzel Spine acquired the PrimaLOK SP Interspinous Fusion System and PrimaLOK FF Facet Fixation System from OsteoMed. Wenzel Spine's VariLi standalone expandable interbody fusion device expands in situ and provides lordotic correction. Xenco Medical (San Diego). In 2017, Xenco Medical launched TraumaGPS, an on-demand trauma surgery delivery app, and expanded delivery for its ASC CerviKit, a compact storage platform for anterior cervical discectomy and fusion procedures in the ASC setting. Xenco Medical's surgical systems stand out from the crowd by ensuring every patient is operated on with single-use implant systems. Zavation (Flowood, Miss.). Zavation is an employee-owned company offering biologics, spinal systems and kyphoplasty and vertebroplasty solutions. Private equity firm LongueVue Capital acquired Zavation Medical Products in 2017. Zavation has a network of more than 100 distributors across 35 states. Zimmer Biomet Spine (Westminster, Colo.). Zimmer Biomet Spine offers solutions for various complex and minimally invasive spine procedures; its MIS portfolio includes the PathFinder NXT Pedicle Screw System and Alpine XC Adjustable Fusion System. Zimmer and Biomet were separate orthopedic device companies that merged in a $14 billion transaction in 2015 to create Zimmer Biomet. In 2016, the combined company acquired LDR Spine, the manufacturer of Mobi C and L artificial discs, for $1 billion. e company also acquired Medtech, which developed the ROSA robotic system for brain and spine surgery, for approximately $132 million. n

• Cover