Becker's Spine Review

55 purchased the company for $20 million in 1987, but management bought out the company in 1999 and made it public in 2001. Blackstone Group purchased DJO in 2007 and merged it with Reable erapeutics. Since then, the company has partnered with several overseas distributors and continues to growth through strategic acquisitions, such as Bell-Horn and Elastic erapy. Exactech (Gainesville, Fla.). Founded in 1985 by an orthopedic surgeon and a biomedical engineer, Exactech provides orthopedic implant devic- es, related surgical instruments and biologic materials and services. e company markets its products in more than 30 markets including the Americas, Europe and the Asian Pacific. In May 2010, Exactech acquired Brighton Partners, the sole-source supplier of the direct compression molded polyethylene bearings used in Exactech's Optetrak knee replace- ment system, in a $5.5 million all cash deal. Implanet (Bordeaux, France). Implanted focuses on spine and knee products. e JAZZ Band is the companies latest generation implant, in- tended to improve the treatment of spinal disorders required for spinal fusion surgery. e company transferred its listing of shares to the Eu- ronext Growth multilateral continuous trading facility from the Euronext regulated market in July 2017, without issuing new shares. e move is expected to simplify administrative burdens and reduce costs. Implanet reported a 19 percent sales growth in the first half of 2017. K2M (Leesburg, Va.). K2M makes spinal stabilization and minimally invasive systems for treatment of complex spinal pathologies and proce- dures. Products involve motion preservation, annular repair and nucleus replacement. John Kostuik, MD, its chairman and co-founder, is former chief of spine surgery at Johns Hopkins University School of Medicine. e company is beginning to market its products in Germany, the UK and Japan. e company reported an 11 percent increase in second quar- ter revnue for 2017, reaching $65.7 million. K2M also signed a long term, exclusive disagreement with Mitsubishi Corp., subsidiary Japan Medical- next to distribute the company's products in Japan. Mazor Robotics (Caesarea, Israel). Mazor Robotics develops and man- ufactures robotic guidance systems for spine and brain surgery. In 2001, the company was founded as M.A.S.O.R Surgical Technologies by Moshe Shoham and Eli Zehavi and renamed Mazor Robotics in 2010. Mazor's first product, SpineAssist, received FDA approval in 2004. In 2016, Mazor launched Mazor X, the next generation spinal robotic system designed to improve pedicle screw placement accuracy. Medtronic purchased 15 sys- tems in a $42 million co-marketing deal. Medicrea (Rillieux-La-Pape, France). Specializing in digital planning and pre and postoperative analytics, Medicrea has more than 30 FDA ap- proved implant technologies. In total, Medicrea technologies have been used in 100,000 spinal surgeries. e company develops and produces 3D printed titanium implants in France. In June 2017, Medicrea received FDA clearance for the UNiD HUB designed to support surgeon work- flow. Meditech Spine (Atlanta). Meditech Spine designs, develops and dis- tributes spinal implant devices. In September 2016, the company re- ceived FDA clearance for the CURE Anterior Cervical Plate System. e system is designed for anterior screw fixation to the C2 to C7 levels of the cervical spine. is year Meditech, in partnership with CURE In- ternational, released CURE Lumbar Plating System, allowing surgeons to utilize the lumbar plating system along with Meditech's lumbar Talos fusion devices. Medtronic (Dublin, Ireland). Formerly based in Minneapolis, Medtron- ic acquired Covidien in 2015 for $49.9 billion and relocated headquarters to Ireland. e company maintains the Minneapolis-based facility and has promised to add jobs in the U.S.. Medtronic's Infuse bone morpho- genetic protein product remains one of the most used synthetic fusion materials in the U.S. e company operates in more than 260 locations in 155-plus countries. In 2016, Medtronic reported $737 million in spine sales, a 1 percent decrease. In total, the company reported $28.8 billion in revenue, a 42 percent increase in 2016. NuVasive (San Diego). NuVasive develops minimally disruptive and procedurally integrated solutions for spinal surgery. Most well known for the eXtreme Lateral Interbody Fusion lateral access procedure, NuVasive also offers the Maximum Access Surgery platform. With 2,300 employ- ees in over 25 locations worldwide, NuVasive reported $962 million in revenue for 2016. In April 2017, NuVasive launched its Reline Trauma portfolio, allowing for a customized approach to surgery. Orthalign (Aliso Viejo, Calif.). OrthAlign makes surgical navigation products for precise alignment. Its palm-sized KneeAlign system is a dis- posable unit for tibial alignment in total knee arthroplasty. KneeAlign is typically lower cost than large console CAS and does not require a CT Scan, MRI or additional x-rays. is past year the company announced its 60,000th joint arthroplasty case and received FDA clearance for its Di- rect Anterior Approach HipAlign system, which provides surgeons with critical measurements to optimize direct anterior total hip replacements. Orthofix (Lewisville, Texas). Established in 1980, Orthofix focuses on developing reconstruction and regenerative orthopedic and spine solu- tions. Orthofix collaborates on research and development with various organizations, including the Musculoskeletal Transplant Foundation, Orthopedic Research and Education Foundation and the Texas Scottish Rite Hospital for Children. e company's strategic business units in- clude BioStim, biologics, extremity fixation and spine fixation. Osseon erapeutics (Santa Rosa, Calif.). e University of Northern California founded Osseon erapeutics as a $14 million startup in 2008. Osseon erapeutics designs, manufactures and distributes systems to correct vertebral compression factures. e company also focuses on bone cement deliver devices and bone cement composite for treating symptomatic vertebral compression fractures. In Januray 2017, Osseon received a new patent for its Steerable and Curvable Cavity Creation Sys- tem, which is designed to treat compression spine fractures. Pacira Pharmaceuticals (Parsippany-Troy Hills, N.J.). Pacira Pharma- ceuticals launched Exparel, a bupivacaine liposome injectable suspension indicated for single-does infiltration into the surgical site for postoper- ative analgesia, in the United States in 2012. In July 2017, the compa- ny published a Phase IV study in the Journal of Arthroplasty showing Exparel reduced patient pain aer total knee arthroplasty from 12 to 48 hours aer surgery, and the company achieved statistical significance in reducing opioid consumption. In the second quarter of 2017, Exparel net product sales reached $69.8 million, up 6 percent over the same period last year. Paradigm Spine (New York City). Established in 2005, Paradigm Spine specializes in non-fusion spinal procedures for patients with spinal ste- nosis. In 2012, the company's coflex Interlaminar Stabilization device re- ceived FDA clearance. In January 2016, a a five-year study published in the International Journal of Spine Surgery found interlaminar stabiliza- tion is an effective and sustainable treatment for spinal stenosis patietns, and wasn't necessarily a precursor to fusion. Paradigm Spine also com- missioned a Miliman study into the economic value of colfex and found cost reduction when compared with primary lumbar fusion. RTI Surgical (Alachua, Fla.). RTI Surgical provides surgeons with bi- ologic, metal and synthetic implants. e implants are used in sports medicine, general surgery, spine, orthopedic, trauma and cardiothoracic procedures. In June 2017, RTI Surgical partnered with Advanced Regen- erative Manufacturing Institute, a public-private manufacturer which

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