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54 Sponsored by: 37 Orthopedic and Spine Device Companies to Know By Mackenzie Garrity Aesculap Implant Systems (Parkway Center Valley, Pa.). Aesculap Implant Systems is the medical device arm of Aesculap USA focused on orthopedic and spine devices. e company's activL artificial disc is FDA approved for one-level lumbar artificial disc replacement. e ac- tivL is the first lumbar artificial disc with a mobile ultra-high molecular weight polyethylene core designed to mimic the movement of a healthy lumbar spine. Aesculap Implant Solutions also provides spinal fusion and minimally invasive spine surgery solutions with the CASPAR Cer- vical Plate and S4 Element MIS System and developed Plasmapore, an innovative surface enhancing technology that complements the PEEK interbody implant. Alphatec Spine (Carlsbad, Calif.). Alphatec Spine works with spine surgeons to design and develop products and systems that address the entire spinal fusion procedure. e company developed Arsenal Degen- erative, a comprehensive system with ergonomically designed instru- ments capable of handling complex pathologies from T1 to the pelvis Later this year, the company plans to fully launch the Battalion Lateral System. Alphatec Spine has a large product portfolio including systems for thoracolumbar support, interbody support, cervical support, mini- mally invasive surgery and biologics. Amedica Corp. (Salt Lake City). Amedica is a spine and orthopedic device company, specializing in silicon nitride technologies for a vari- ety of medical applications. Silicone nitride is bioactive and compatible across all imaging modalities, offering an alternative to commonly used materials. Amedica is the only FDA registered and ISO 13485 certified nitride medical device manufacturing facility. In 2008, the company first received FDA clearance for their silicon nitride spinal fusion device, Va- leo. In addition, Amedica developed Preference 2 Pedicle Screw Systems designed to reduce surgery time and improving surgeon ease of use. Arthrex (Naples, Fla.). A global medical device company focusing on product development and medical education in orthopedics, Arthrex has developed 11,000 products and surgical procedures to advance min- imally invasive orthopedics. Arthrex is dedicated to patient safety and clinical outcomes. e company is developing new technologies with potential multispecialty applications. In 2015 and 2016, FORTUNE list- ed Arthrex among the 100 Best Companies to Work For. Aspen Medical Products (Irvine, Calif.). Aspen Medical Products de- signs, develops and markets upper and lower spinal orthotics. e com- pany was established in June 2000 aer International Healthcare Devic- es, the product development and marketing branch for Aspen Cervical Collars and CTOs, merged with Fiji Manufacturing. Aspen Medical Products was recognized as one of the Best Places to Work in California by OC Business Journal from 2009 to 2015. Aurora Spine (Carlsbad, Calif ). Aurora Spine specializes in minimally invasive regenerative technology.. In 2014, Aurora Spine's ZIP 51, a min- imally invasive interspinous fixation implant, received FDA clearance. Surgeons around the world use Aurora's spinal technology, with the first procedure performed in Argentina in August 2017. A month earlier, Au- rora received a loan of $350,000 for general corporate purposes. Bioventus (Durham, N.C.). Bioventus was established in 2012 when the biologics division of Smith & Nephew partnered with Essex Wood- lands. Bioventus specializes in orthobiologics and enhancing the natural healing process. Products and services include Bioventus Active Heal- ing therapies and Bioventus Surgical. e company has 660 employees worldwide and generates approximately $250 million in yearly revenue. Camber Spine Technologies (Wayne, Pa.). Camber Spine Technologies focuses on surgeon designed solutions for minimally invasive and min- imally disruptive access to the spine. e company launched its Enza Zero-Profile ALIF devices in July 2016 and a year later surgeons have performed more than 150 procedures using the technology. In Jan. 2017, the company received FDA clearance for its Siconus SI Fusion Screw System, which provides fixation and stabilization of large bones, includ- ing the sacrum and ilium. ChoiceSpine (Knoxville, Tenn.). ChoiceSpine is a privately held spinal implant company located in Knoxville, Tenn. Founded in 2006, Choice offers an extensive array of innovative, surgeon focused systems de- signed with the best clinical outcomes in mind. In addition, ChoiceSpine offers a full regenerative and osteobiologics portfolio including synthet- ics, DBM's, structural allogra and amnion allogras. With cutting edge technology in their Veo™ VLIF lateral fusion line to the incorporation of Hydroxyapetite (HA) in their PEEK® interbody systems, ChoiceSpine is committed to always staying ahead of market trends and to provide surgeons with dynamic solutions for their patients. ConforMIS Corp. (Burlington, Mass.). Founded in 2004, ConforMIS uses iFit image-to-implant technology to develop, manufacture and sell individually sized and shaped joint replacement implants. In recent clin- ical studies, the company's iTotal CR, the cruciate-retaining total knee replacement implant, showed positive clinical outcomes, including bet- ter function and greater patient satisfaction. DePuy Synthes (Warsaw, Ind.). Part of the Johnson & Johnson family of companies, DePuy Synthes offers various orthopedic and neuro prod- ucts and services for joint reconstruction, trauma, spine, sports medi- cine, cranio-maxillofacial, power tools and biomaterials. e company was established in 1895 as Revera DePuy. In 1998, Johnson & Johnson acquired Revera DePuy and later in 2012 the global device company Synthes. Today DePuy Synthes employs approximately 18,000 people across 60 counties, generating $10 billion in annual sales. With its ex- tensive portfolio, the company supports nearly 1 million orthopedic and spine procedures worldwide annually. DJO Global (Vista, Calif.). DJO Global is an orthopedic device compa- ny with products used for surgery, rehabilitation, pain management and physical therapy. Founded in 1978 as DonJoy, DJO Global's first products were neoprene sleeves to pull over joints for support. Smith & Nephew