Becker's Spine Review

56 ChoiceSpine (Knoxville, Tenn.). ChoiceSpine is a privately held spinal implant company located in Knoxville, TN. Found- ed in 2006, Choice offers an extensive array of innovative, surgeon focused systems designed with the best clinical outcomes in mind. In addition, ChoiceSpine offers a full regenerative and osteobiologics portfolio including synthetics, DBM's, structural allograft, and amnion allografts. With cutting edge technology in their Veo™ VLIF lateral fusion line to the incorporation of Hydroxyapetite (HA) in their PEEK® interbody systems, ChoiceSpine is committed to always staying ahead of market trends and to provide surgeons with dynamic solutions for their patients. brings together nearly 100 partner organizations to develop processes and technologies for cells, tissues and organs. SI-Bone (Cupertino, Calif.). A spin-off company created aer Wright Medical bought INBONE Technology, SI-Bone was established in April 2008. SI-Bone specializes in minimally invasive sacroiliac joint replace- ments. e company's iFuse Implant System uses titanium implant tech- nology for sacroiliac fusion. More than 1,000 surgeons have performed more than 25,000 procedures with SI-Bone's iFuse implant system. Around 50 journal articles and publications support the use of iFuse. In January 2017, SI-Bone launched a warranty program for iFuse to guaran- tee results of the procedure. Smith & Nephew (London, England). Smith & Nephew develops prod- ucts and services for orthopedic reconstruction, wound management, sports medicine, trauma and extremities. In 2016, the company reported annual sales of $4.6 billion and closed a $275 million acquisition of Blue Belt Technologies' Navio robotic-assisted surgery system. In June 2017, Smith & Nephew released the Navio application for total knee replace- ments, supporting the Journey II, Legiona Primary and Genesis II Total Knee Systems. Spinal Motion (Mountain View, Calif.). Founded in 2004, Spinal Mo- tion makes artificial discs for use in the spine. e company has applied for premarket approval of its Kineflex Disc for lumbar cases, and the Kineflex C Disc for cervical cases. ese are weight-bearing, modular implants consist of two keeled endplates and one semi-constrained, fully articulating cobalt chrome core. In 2009, Spinal Motion secured $27.4 million in Series D funding and reached 20 percent enrollment for a lat- erally placed lumbar artificial disc clinical study. SpineGuard (St. Mande, France). Founded in 2009, SpineGuard de- velops spine devices through its Dynamic Surgical Guidance platform in partnership with medical device companies. is technology helps surgeons treating spinal instabilities and deformities. SpineGuard's PediGuard device has been used during 55,000 pedicle screw placement procedures worldwide. In January 2017, the company received FDA clearance to market the Dynamic Surgical Guidance in combination with Zavation's spinal fusion system. Stryker Corp. (Kalamazoo, Mich.). Stryker is a seasoned player cover- ing all key applications of hip, knee, upper Founded in 1941, extremity and spinal implants. Since 2013, Stryker has made a slew of acquisitions including MAKO Surgical for $1.65 billion, Trauson for $764 million, Small Bone Innovations for $375 million, Physio-Control for $1.28 bil- lion and most recently Novadaq Technologies for $701 million. In 2016, Stryker reached $11.3 billion in sales and reported 33,000 employees globally. Titan Spine (Mequon, Wis.). Founded in 2006, Titan Spine focuses on titanium implants for spinal fusion procedures. e company's revolu- tionary surface technology promotes fusions. In 2017, Titan Spine re- ported the nanoLOCK Endoskeleton interbody fusion device was use in its 1,000 surgeries. e company offers a one-time free replacement warranty on Endosekelton devices. In the second quarter of 207, Titan Spine reported nanoLOCK sales volume increased 42 percent over the first quarter and has achieved 2,500 implantations since launching in Oc- tober 2016. TranS1 (Wilmington, N.C.). TranS1 develops products to solve spinal pathologies while minimizing trauma to the tissues surrounding the spine. e products are designed to build a foundation upon the L5-S1 joint. Currently, TranS1 is participating in 85 studies to research the safe- ty and efficacy of AxiaLIF+ for spinal fusion at the L5-S1 joint. In 2016 the company was recognized as the Most Innovative Workplace in Den- ver and was a finalist for the Technology Association's Apex Awards. In 2017, TranS1 launched its Capital Bone Gra Harvester. e new tech- nology is designed for fast, reliable and reproducible harvesting of auto- gra material from the iliac crest. Vertiflex (San Clemente, Calif.). In 2015, Vertiflex received FDA clear- ance for its Superion Interspinous Spacer System. Superion is designed from moderate lumbar spinal stenosis and to be a minimally invasive motion preserving device. Vertiflex is devoted to providing advanced and minimally invasive treatments for lumbar stenosis. e company's Totalis Direct Decompression System is designed to safely perform minimally invasive direct decompressions of the lumbar spine. Wright Medical Technology (Arlington, Tenn.). Wright Medical Tech- nology specializes in developing products and instruments for different areas of orthopedics, including upper extremities, lower extremities and biologics. e company's products aim to alleviate pain and restore life- styles and are available in more than 60 countries. Wright completed its acquisition of BioMimetic erapeutics in 2013 for $42.5 million. at same year, Wright acquired French orthopedic extremities company Bio- tech International for $75 million. Zimmer Biomet (Warsaw, Ind.). Zimmer and Biomet were both consid- ered orthopedic device company giants when they merged in June 2015 to create Zimmer Biomet in a $14 billion transaction. In 2016, the com- bined company acquired LDR Spine, the maker of Mobi C and L artificial discs, for $1 billion and Medtech, which developed the ROSA robotic system for brain and spine surgery for around $132 million. Zimmer Biomet operates in 25 countries around the world and sells products in more than 100 counties. e Progress IV clinical trial evaluates the safety and clinical effectiveness of autologous protein solutions, prepared from a small sample of a patient's own blood with an investigational device called the nSTRIDE APS Kit, on pain and function associated with knee osteoarthritis. Zyga Technologies (Minnetonka, Minn.). Zyga was founded in 2008 to develop technology for resurfacing the fact joint. In 2009 the company centered its focus on developing products for minimally invasive surgery to fuse the sacroiliac joint. e SImmetry Sacroiliac Joint Fusion System is a minimally invasive spine surgery procedure designed to help stabi- lize the SI joint. Zyga also developed its Glyder Facet Restoration Device. e device is intended to provide relief from lumbar facet pain, restoring fact joint function while preserving anatomy. Earlier this year, Zyga an- nounced its 100th patient to enroll in the EVoluSIon clinical study. e clinical study evaluates long term fusion and pain reduction in patients receiving SImmetry Sacroiliac Joint Fusion. n

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