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17 6 Market Leaders Drive Anterior Cervical Fixation Devices Market — Globus Medical, J&J, Medtronic & More By Megan Wood T echnavio revealed the top six vendors in the global anterior cervical fixation devices space. e market is anticipated to grow slowly between 2016 and 2020, because the dominating Amer- icas may have reached their peak with industry adoption of cervical disc replacement devices. e report found leading vendors are outsourcing to manufacturers to save time. Instead, they focus time on design and development of new spinal implants. e result of this strategy enhances the companies' de- pendence on contract manufacturers. Here are the top six vendors in alphabetical order: 1. Globus Medical offers fusion products designed to treat degener- ative diseases, deformity as well as tumor and trauma conditions. e company focuses most of its efforts in the U.S. market. With a portfolio of more than 130 products for spine disorder treatment, Globus Medical is currently developing 30 new products. 2. Johnson & Johnson sells its orthopedic and neurological devices through its subsidi- ary, DePuy Synthes. e company's portfolio includes products for internal and external fix- ation, pain management and minimally invasive procedures. 3. Medtronic offers products in this market through its restorative therapies group, which saw a revenue of $6.75 billion in fiscal year 2015. e company's portfolio includes fixation sys- tems designed to treat degenerative disc disease, spinal tumors, spine fractures, spinal deformity and stenosis. 4. NuVasive's products are designed for cer- vical fusion procedures. e company's acquisi- tion of Ellipse Technologies will likely increase its revenue. 5. Stryker develops fixation systems and spac- ers for the market, selling through its neuro- technology and spine segment. e products are designed for minimally invasive endovascular techniques, spinal injury, deformity and degen- erative therapies. In fiscal year 2015, this seg- ment saw a revenue of $1.82 billion, with spine products bringing in $740 million. 6. Zimmer Biomet provides market products through its spine, craniomaxillofacial and tho- racic segment. e company's fixation systems, spacers and fusion devices are intended for pa- tients with degenerative conditions. e segment brought in $404.4 million in fiscal year 2015. n The power of design. SIGNAFUSE represents a new class of orthobiologics designed for sustained bioactivity, optimized integration, and best-in-class handling. SIGNAFUSE establishes the ideal environment for bone healing from beginning to end, with an optimized resorption profi le and the ability to mimic the natural structure of bone. 1 Keeping surgeons in mind, SIGNAFUSE is designed for superior handling properties and an easy to use format. Learn more about SIGNAFUSE and our full portfolio at BioventusSurgical.com SIGNAFUSE is a bone void fi ller device intended for use in bony voids or gaps that are not intrinsic to the stability of bony structure. These defects may be surgically created osseous defects or osseous defects created from traumatic injury to the bone. SIGNAFUSE is indicated to be packed gently into bony voids or gaps of the skeletal system (i.e., extremities, pelvis and posterolateral spine fusion procedures). SIGNAFUSE can also be used with autograft as a bone graft extender in posterolateral spine. The device provides a bone void fi ller that is resorbed and replaced with host bone during the healing process. 1. Data on fi le. RPT-000541 BioStructures Technical Whitepapers. ©2016 Bioventus LLC I Bioventus, the Bioventus logo, and SIGNAFUSE are registered trademarks of Bioventus LLC. I SMK-001880 I 09/16 Bioactive Surface Response SEM images of surface apatite layer formation on the implant surface following immersion in simulated body fluid Time 0 - Unreacted 1 Day 7 Days "The market is anticipated to grow slowly between 2016 and 2020, because the dominating Americas may have reached their peak with industry adoption of cervical disc replacement devices."