Issue link: https://beckershealthcare.uberflip.com/i/730929
15 SPINE LEADERSHIP The power of a unique process. OSTEOAMP does more than just provide the structural scaffold for bone growth. Its unique process delivers an allograft with the clinical benefit of growth factors found in bone and bone marrow. OSTEOAMP provides essential elements supporting bone formation, backed by science, to meet the surgeon's need for a proven allograft that can achieve solid fusion outcomes. OSTEOAMP may be used in situations where an autograft is appropriate, such as spinal fusion procedure. It should be restricted to homologous use for the repair, replacement or reconstruction of musculoskeletal defects. Please see OSTEOAMP instructions for use for complete list of contraindications, warnings, and precautions. 1. RPT-000327 Report on Growth Factor Concentrations in Bone and Bone Marrow Aspirate, December 3, 2010, Advanced Biologics, LLC. Data from a single lot of OSTEOAMP sponge product. 2. High levels relative to those reported in published literature for other allografts. 3. Bae H, Zhao L, Zhu D, Kanim L, Wang J, Delamarter R. Variability Across Ten Production Lots of a Single Demineralized Bone Matrix Product. J Bone Joint Surg Am. 2010; 92:427-35. ©2016 Bioventus LLC. I Bioventus, the Bioventus logo, and OSTEOAMP are registered trademarks of Bioventus LLC. I SMK-001743 I 06/16 Learn more about OSTEOAMP and our full portfolio at BioventusSurgical.com The Art and Science of Orthobiologics. OSTEOAMP maintains and preserves a wide array of naturally occurring growth factors found in bone and bone marrow at high levels to deliver clinical results (such as aFGF, BMP-2, BMP-7, TGF-ß1). 1,2,3 12,000 10,000 8,000 6,000 4,000 2,000 0 CONCENTRATION (ng/g) aFGF BMP-2 BMP-7 TGF-B1 aFGF BMP-2 BMP-7 TGF-B1 Quantitative Analysis of Growth Factors in OSTEOAMP 5 Health Systems With Strong Finances By Ayla Ellison H ere are five health systems with strong operational metrics and solid financial positions based on recent reports from Moody's Investors Service, Fitch Ratings and S&P Global Ratings. 1. Duke University Health Sys- tem has an "AA" rating and sta- ble outlook with S&P Global Ratings and an "Aa2" rating and stable outlook with Moody's. The Durham, N.C.-based system has strong balance sheet ratios and a stable leadership team, according to S&P. 2. Children's Healthcare of At- lanta has an "Aa2" rating and sta- ble outlook with Moody's. The sys- tem has a track record of strong margins and liquidity, according to Moody's. 3. Flint, Mich.-based McLar- en Health Care has an "AA-" rating and stable outlook with Fitch. The system has a leading market share in its primary service area. 4. Nebraska Medicine has an "AA-" rating and stable outlook with Fitch an "AA-" rating and stable outlook with S&P. The Omaha-based system has a broad operating platform and low debt burden, according to Fitch. 5. Memphis, Tenn.-based Meth- odist Le Bonheur Healthcare has an "AA-" rating and stable outlook with S&P. The system has a strong enterprise profile and leading market share in its service area, according to S&P. n