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23 unite patient care with education and research. Today, Johns Hopkins Hospital houses a total of 1,059 beds and 33 operating rooms, as well as Level I trauma services. e walls of the hos- pital's Zayed Tower and Bloomberg Children's Center are adorned with art from renowned artists, including Spencer Finch, Robert Israel and Jim Boyd, among others. Johns Hopkins counts many firsts among its early achievements. It was the first major med- ical school in the U.S. to admit women, the first to use rubber gloves during surgery and the first to develop renal analysis and CPR. In March of this year, the hospital hosted the world's first-ever liver transplant involving an HIV-positive donor and recipient. Johns Hopkins Hospital was ranked as the No. 1 hospital in Maryland and tied for the No. 3 hospital in the nation overall in U.S. News & World Report's 2015-16 rankings. It is nation- ally ranked in 15 adult specialties and 10 pe- diatric specialties. Johns Hopkins Hospital is Magnet-accredited by the American Nurses Credentialing Center. Lehigh Valley Hospital–Cedar Crest (Allen- town, Pa.). Lehigh Valley Hospital's roots date back to 1899, when 13 women raised $5,300 for a plot of land in Allentown to open a hospital for their community. e hospital is the flag- ship location of the Lehigh Valley Health Net- work, which is comprised of three full-service hospitals and more than 1,340 primary care and specialty physicians. In 2014, the health network formed the Le- high Valley Health Network Accountable Care Organization, a subsidiary of Lehigh Health Network, to participate in the CMS Medicare Shared Savings Program. e ACO serves the Lehigh Valley region of Pennsylva- nia, including Lehigh, Northampton, Carbon and surrounding counties. In 2015 and 2016, Lehigh Valley Hospital–Ce- dar Crest was listed among the nation's 50 Best Hospitals by Healthgrades. U.S. News & World Report ranked the hospital No. 3 in Pennsyl- vania in its 2015-16 rankings. It is ranked na- tionally in seven adult specialties and rated as high performing in four adult procedures and conditions by U.S. News as well. Loyola University Medical Center (May- wood, Ill.). Loyola University Medical Cen- ter is a 559-bed academic medical center and teaching hospital firmly rooted in the Jesuit Catholic faith. e hospital belongs to Loyola Medicine, a quaternary-care system with a 61- acre medical center campus in the western sub- urbs of Chicago. In 2015, LUMC was ranked nationally by U.S. News & World Report in four adult specialties and ranked the No. 3 hospital in both the state of Illinois as well as the Chicago metro area. It has been accredited by the Commission on Accreditation of Rehabilitation Facilities and has maintained its status as a Magnet hospital by the American Nurses Credentialing Center since 2009. Additionally, the hospital earned an "A" hospital safety score from the Leapfrog Group for fall 2015. Loyola University Medical Center boasts sev- eral well-respected specialty programs, includ- ing a burn center that treats more than 4,000 patients annually, roughly 40 percent of whom are children. e burn center was awarded verification by the American College of Sur- geons and the American Burn Association. Along with Loyola's Burn and Shock Trauma Institute, the burn center is also involved in research on postburn immunosuppression and wound healing, among other concentrations. Massachusetts General Hospital (Bos- ton). Founded in 1811, Massachusetts Gener- al Hospital is the third oldest general hospital in the U.S. and the first teaching hospital of Harvard Medical School. Today, it is consid- ered the No. 1 overall hospital in the nation, according to U.S. News & World Report's 2015-16 rankings, and it is Magnet-designat- ed for nursing excellence. During its more than 200-year history, MGH has grown into a 999-bed medical center with a Level I trauma center and burn center. e hospital's emergency room handled more than 95,000 patient visits last year. It is also a major research hub, with an annual research bud- get of more than $786 million and a program spanning more than 20 clinical departments. MGH's focus on research has led to several medical milestones at the hospital. For example, in 1964, MGH research made long-term stor- age of human blood a practicality and in 1962 surgeons there performed the first successful reattachment of a severed human limb. More recently, 1987, MGH researchers contributed to the discovery of the first gene associated with in- herited early-onset Alzheimer's disease. Mayo Clinic (Rochester, Minn.). Founded in 1889, Mayo Clinic is the first and largest inte- grated nonprofit medical group practice in the U.S. e Mayo Clinic's Rochester campus is made up of two hospitals, 794-bed Mayo Clinic Hospital, Methodist Campus, and the 1,265-bed Mayo Clinic Hospital, Saint Marys Campus. Together, Mayo Clinic in Rochester is home to roughly 2,192 staff physicians and scientists. e Minnesota-based Mayo Clinic is ranked nationally in 15 adult specialties — eight of which were in first place — and 10 pediatric specialties by U.S. News & World Report in 2015-16. e Mayo Clinic's campuses in Jack- sonville, Fla., and Phoenix, Ariz., are also highly ranked by the publication. Mayo Clin- ic received a Healthgrades 50 Best Hospitals ranking in 2015 and has consistently made the list of "100 Best Companies to Work For" by Fortune magazine. Mayo Clinic in Rochester offers onsite well- ness services — such as health cooking classes, yoga, Pilates and a masseuse — to enhance the lives of its patients, their families and employ- ees. e health system spends in excess of $500 million on research annually. ere are several research centers and programs based at Mayo in Rochester, including the first center for in- novation that was integrated into a medical practice setting. Medical University of South Carolina (Charleston). e Medical University of South Carolina opened in 1824 as a small private college for the training of physicians. e school has since grown into a state uni- versity with a medical center and six colleges for the education of healthcare professionals, biomedical scientists and other health per- sonnel. With an overall population of about 13,000 clinicians, faculty, staff and students, its campus is located on more than 80 acres in Charleston. MUSC Health trains 2,600 healthcare professionals each year. e 700-bed Magnet-recognized medical center was ranked nationally in one adult specialty and one pediatric specialty, and was recognized as the No. 1 hospital in South Car- olina by U.S. News & World Report in 2015- 16. In Charleston City Paper's 2016 "Best of Charleston" list, assembled by popular vote, MUSC and MUSC Health were voted Best Hospital, Best Place to Work, Best Health Club and Best Weight Loss Center. In addition to its training and patient care prowess, MUSC Health is also a leading re- search facility. In fiscal year 2013, the medical center received $232 million in total external funding, and $93.5 million in National Insti- tutes of Health funds. One research focus is depression, as the MUSC Health Depression Research and Treatment Center is a member of the National Network of Depression Centers, studying and treating depression and related neuropsychiatric disorders. Memorial Sloan Kettering Cancer Center (New York City). Memorial Sloan Kettering Cancer Center is composed of two related in- stitutions: Memorial Hospital for Cancer and Allied Diseases and Sloan Kettering Institute. Memorial Hospital was founded in 1884 as New York Cancer Hospital. In the 1940s, Al- fred P. Sloan and Charles F. Kettering donated money to build the Sloan Kettering Institute, and in 1960, the two institutions merged. To- day, it is considered the oldest private cancer center in the world.