RAISING THE RAISING THE RAISING THE
GOLD STANDARD IN GOLD STANDARD IN GOLD STANDARD IN
INTEGRATED INTERBODY™ INTEGRATED INTERBODY™
INTEGRATED INTERBODY™
The team at Centinel Spine™ pioneered titanium coatings
on spinal implants over 15 years ago. Centinel Spine
continues to engineer and develop these coatings to
advance the standard of care in spinal fusion procedures.
Ti-ACTIVE™ leverages Centinel Spine's experience and
passion by offering a scientifi cally-proven coating
that promotes bone-forming cellular attachment and
proliferation not typically seen on uncoated PEEK spinal
devices.
1, 2, 3
1
References on File / Internal Reports; Centinel Spine, Inc. LBL073 Rev 1.
2
Olivares-Navarrete R, et al. Osteoblasts exhibit a more di erentiated phenotype and increased bone morphogenetic protein production on titanium alloy substrates than on poly-ether-ether-ketone. Spine J. 2012; 12:265-272.
5
Lebl DR, et al. The mechanical performance of cervical total disc replacements in vivo: prospective retrieval analysis of Prodisc-C devices. Spine (Phila, PA 1976) 2012 Dec 15; 37(26): 2151-60.
Centinel Spine™, Inc.
LBL103 rev 1
A LEGACY OF SCIENCE PROVES NOT ALL
TITANIUM COATINGS ARE CREATED EQUAL
WITH
Ti-ACTIVE™ is a texturized, titanium
coating with a bioactive surface engineered
for growth with:
• 3D OSTEOCONDUCTIVE ENVIRONMENT.
• INCREASED CELLULAR ATTACHMENT.
• ACCELERATED STEM CELL PROLIFERATION.
— 20µm —
— 20µm —
3D OSTEOCONDUCTIVE ENVIRONMENT:
SEM Image (2,000x magnifi cation) of the surface
of a standard PEEK implant (left) and titanium-
coated PEEK implant (right). Unlike standard PEEK,
the 3-D microporous surface of the titanium-coated
PEEK provides an environment conducive to cellular
attachment and proliferation.
1, 2, 3
900 Airport Road, Ste. 3B, West Chester, PA 19380 T: 484.887.8810 F: 800.493.0966 cs@centinelspine.com www.centinelspine.com
MIDLINE II -Ti™
No-Profi le
®
Anterior Lumbar
INTEGRATED INTERBODY
™
System
COMING
SOON
STALIF C-Ti™
No-Profi le
®
Anterior Cervical
INTEGRATED INTERBODY
™
System
NOW
AVAILABLE
MEET THE NEWEST MEMBERS OF
THE STALIF® FAMILY FEATURING Ti-ACTIVE™
TO LEARN MORE ABOUT
Ti-ACTIVE™, PLEASE VISIT
ti-active.centinelspine.com
