Becker's Hospital Review

Important dosing considerations for ARISTADA INITIO and ARISTADA • For patients who have never taken aripiprazole, establish tolerability with oral aripiprazole prior to initiating ARISTADA or ARISTADA INITIO 1,3 • ARISTADA INITIO and ARISTADA are only to be administered as an intramuscular injection by a healthcare professional 1,3 • There are 2 ways to start treatment with ARISTADA. If not starting ARISTADA with the ARISTADA INITIO regimen, administer 21 consecutive days of oral aripiprazole with the first ARISTADA injection 1 • Adjust ARISTADA dose as needed. When making dose and dosing interval adjustments, consider the pharmacokinetics and prolonged-release characteristics of ARISTADA. ARISTADA INITIO is a single dose, and adjustments are not possible 1,3 • If/when a dose of ARISTADA is missed, administer the next injection as soon as possible. Concomitant supplementation following a missed dose may be recommended depending on the time elapsed since last injection. See full Prescribing Information for more information 1 * The ARISTADA INITIO regimen is defined as a single injection of ARISTADA INITIO (675 mg) given in conjunction with a single 30 mg dose of oral aripiprazole.' Learn more about the treatment experiences of real patients at aristadahcp.com/patient-stories. Be certain your patients receive a complete LAI initiation from the start Starting long-acting injectables (LAIs) can be challenging—they take time to reach therapeutic levels and often require multiple steps. ARISTADA INITIO® (aripiprazole lauroxil) is a one-time dose that reduces oral aripiprazole supplementation to 1 day when starting ARISTADA treatment. With the ARISTADA INITIO regimen* and ARISTADA 1064 mg, know in a single visit that your patients have medication on board for 2 full months. 1,3,4 Kelsey, 27, treated with the ARISTADA 2-month dose (1064 mg) Kelsey, 27, treated with the ARISTADA 2-month dose (1064 mg) Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the 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the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the Kelsey, 27, treated with the ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose 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dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) Kelsey, 27, treated with the Kelsey, 27, treated with the ARISTADA 2-month dose (1064 mg) ARISTADA 2-month dose (1064 mg) Know that treatment is ongoing over the 2-month (1064 mg) dosing interval, which may be helpful during the transition from inpatient to outpatient care. 1,2 Additional dosing options are available: 441 mg monthly, 662 mg monthly, and 882 mg monthly or every 6 weeks. 1 The efficacy of ARISTADA® (aripiprazole lauroxil) 441 mg monthly and 882 mg monthly was established in the phase 3 clinical trial. The efficacy of ARISTADA 662 mg monthly, 882 mg every 6 weeks, and 1064 mg every 2 months was established by pharmacokinetic bridging, which demonstrated that these dosing regimens resulted in plasma aripiprazole concentrations that are within the range provided by doses of 441 mg monthly and 882 mg monthly. 1 Start treatment with discharge in mind INDICATION and IMPORTANT SAFETY INFORMATION for ARISTADA INITIO® (aripiprazole lauroxil) and ARISTADA® (aripiprazole lauroxil) extended-release injectable suspension, for intramuscular use INDICATION ARISTADA INITIO, in combination with oral aripiprazole, is indicated for the initiation of ARISTADA when used for the treatment of schizophrenia in adults. ARISTADA is indicated for the treatment of schizophrenia in adults. IMPORTANT SAFETY INFORMATION FOR ARISTADA INITIO AND ARISTADA WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. ARISTADA INITIO and ARISTADA are not approved for the treatment of patients with dementia-related psychosis. Please see additional Important Safety Information and Brief Summaries of full Prescribing Information, including Boxed Warning, for ARISTADA INITIO and ARISTADA on the following pages. Sponsored by Alkermes Give me symptom reduction that stays with me for 2 months at a time FOR ADULTS WITH SCHIZOPHRENIA

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