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32 DEVICES & IMPLANTS 7 spine device company powerhouses: What are they up to in 2018? By Megan Wood T he global spinal surger y devices market is expected to reach $13 billion by 2022, according to a Wise Guy Reports analysis. Here are statistics and facts about seven de- vice companies dominating the spine space. Companies are listed in alphabetical order. DePuy Synthes (Raynham, Mass.) A part of New Brunswick, N.J.-based Johnson & Johnson, DePuy Synthes saw a 1.1 percent sales growth in the first quarter of 2018, com- pared to the first quarter of 2017. e com- pany's spine business sales experienced the greatest decline, at 8.9 percent, reaching $804 million. J&J's orthopedic segment dropped to $9.25 billion in 2017 full-year sales, com- pared to $9.33 billion in 2016. Here's what the company has been up to in 2018: • In April, DePuy Synthes unveiled its PROTI 360° Integrated Titanium Fam- ily of interbody devices, intended for patients with degenerative disc disease. • In May, the company entered into an exclusive agreement with Prosidyan to promote the Fibergra product family for spine fusion surgery. • e Institution of Mechanical Engi- neers recognized DePuy Synthes in Feb- ruary for promoting female engineers. e company's DePuy Synthes' research and development team in Leeds, West Yorkshire, England, is 37 percent fe- male. e national average for female engineers in the U.K. is 11 percent. Globus Medical (Audubon, Pa.) For the first quarter of 2018, Globus Medi- cal reported an 11.9 percent increase in global sales to $174.4 million. e company report- ed $12.8 million in revenue from emerging technologies, partially due to demand for the company's ExcelsiusGPS robotics navigation system. e U.S. spine business grew 4 per- cent in the first quarter over the first quarter of 2017 on a day-adjusted basis. Globus plans to invest in imaging, navigations, robotics and trauma in the future. e company saw glob- al sales of $636 million in full-year 2017. Here's what the company has been up to in 2018: • In April, the company introduced Elsa AL and Elsa-ATP, two expandable in- terbody spacers with screw fixation. • In May, Globus entered a licensing and distribution agreement with Fovia, combining Fovia's XStream HDVR with Globus Medical's ExcelsiusGPS. • Globus Medical, alongside other spine device companies, is collaborating with the Scoliosis Research Society, Interna- tional Spine Study Group Foundation to complete the Adult Symptomatic Lum- bar Scoliosis 2 study. K2M (Leesburg, Va.) K2M's 2018 first quarter revenues in- creased 10 percent year-over-year, hitting $67.88 million. It's U.S. complex spine busi- ness saw an 8 percent growth year-over-year. In the first quarter of 2018, the segment brought in $18.51 million in revenue. e company's minimally invasive segment grew to $8.38 million in the first quarter of 2018. K2M reported 2017 revenue of $258 million. Here's what the company has been up to in 2018: • K2M entered in a compatibility and co-marketing agreement with Brain- lab. e companies are still planning a commercial launch in the second half of 2018. During the first quarter conference call, K2M CEO Eric Major said, "e en- gineering teams are working closely on the compatibility of K2M spinal systems and instrumentation with Brainlab's in- traoperative imaging guided navigation and imaging platforms." • In March, the company launched its Yukon OCT Spinal System, designed to help surgeons restore cervical sagittal balance through posterior fixation. • K2M is also collaborating with the Scoliosis Research Society, Interna- tional Spine Study Group Founda- tion to complete the Adult Symp- tomatic Lumbar Scoliosis 2 study. Medtronic (Dublin, Ireland) Medtronic reported $3.7 billion in third quarter 2018 revenues. e company's spine revenue reached $661 million, a 1 percent increase year-over-year. Medtronic report- ed $7.4 billion in sales for fiscal year 2017. Here's what the company has been up to in 2018: • Medtronic took over global commercial responsibility for Mazor X installations. • Medtronic continues to push for more outcome-based contracts. e compa- ny is signing contracts with customers to adjust prices based on how well the specific product works rather than hav- ing a customer paying a fixed price for a product despite its performance. • In May, the company revealed its Syn- ergyTLIF(SM) workflow for minimal- ly invasive spine surgery as well as its TiONIC Technology, a titanium 3D printed platform for spinal implants • Medtronic named Chris Lee president of the Asia-Pacific region in January and appointed Laura Mauri, MD, its new vice president of global clinical re- search and analytics in April. • Medtronic is another spine company collaborating with the Scoliosis Research Society, International Spine Study Group Foundation to complete the Adult Symp- tomatic Lumbar Scoliosis 2 study. • Medtronic presented a plan to restruc- ture the company in January, hoping it will result in result in $3 billion-plus in annual growth savings by the end of fis- cal year 2022. NuVasive (San Diego) NuVasive saw 2018 first quarter revenues in- crease 4.6 percent year-over-year to $260.5 million. e company's full-year 2017 reve- nue hit $1.03 billion. Here's what the company has been up to in 2018: • NuVasive launched its Coalesce ora- columbar Interbody Fusion Device in January and received expanded FDA clearance for Coalesce and its Cohere